Regulatory effect of epinephrine on major ion channels in repolarization of ventricular papillary muscle cells / 中国药理学通报

ABSTRACT

In some states such as myocardial ischemia, heart failure, angina pectoral and myocardial ion channel disease and so on, one person may catch with a rapid cardiac arrhythmia, e-ven a generate ventricular fibrillation or a sudden death, especially in the case of emotional agitation, stress or sympathetic tone increasing abnormally, and exogenous administration of epinephrine , followed by a significant rising of catecholamine. All the above have a relationship with the sympathetic excitatory for ct and p receptors, the regulation of myocardial ion channel function, changing the myocardial action potential, and the myo cardial excitability. From the perspective of myocardial electro-physiology , this paper analyzes the effect of adrenal receptors on the regulation of ion channels, which plays a main action in the myocardial depolarization process, as well as the effect on the action potential duration, aiming to deepen the understanding of the mechanism of catecholamine inducing ventricular arrhythmias.