Research progress of signaling pathways involved in expression of hypoxia-inducible factor-la in rheumatoid arthritis / 中国药理学通报

ABSTRACT

Rheumatoid arthritis (RA) is a systemic autoimmune disease whose development is closely related to the hypoxic mi-croenvironment of joints. Hypoxia-inducible factor-1 a (HIF-la) is a nuclear transcription factor that regulates cellular responses to hypoxia and plays an important role in promoting synovial inflammation, angiogenesis, pannus formation, cartilage destruction and bone erosion. In addition to regulation by oxygen receptors, its expression is regulated by multiple signal transduction pathways, including PI3K/Akt, Ras-Raf-MEK-ERK, JAK/STAT and NF-kB , etc. This article provides an overview of the signaling pathways involved in the regulation of HIF-la expres-sion, in order to provide new ideas and evidence for the treatment of RA and the search for new disease modifying antirheumatic drugs.