Research progress on structural modification of α1-adrenergic receptor influencing its biological activities and its physiological function / 中国药理学通报

ABSTRACT

The α1-adrenergic receptor (α1-AR) belongs to G-protein coupled receptors (GPCRs) and contains three subtypes, namely α1A, α1B and α1D. Studies have shown that structural changes in the α1-ARs receptor can lead to changes in their physiological functions. In the present study, we summarize the structural changes in four aspects of α1-ARs receptors, including carboxy-terminal truncation, dimerization, allosteric effects, and point mutations that lead to endocytosis, phosphorylation, desensitization, and affinity for agonists.