Research progress of zinc finger protein A20 in allergic asthma / 中国药理学通报

ABSTRACT

A20 (also known as TNFAIP3 ) is a zinc finger which can be activated by a variety of inflammatory factors such protein with both ubiquitination and deubiquitination functions, as LPS, IL-1 and TNF-α. To date, A20 has been considered a negative regulator of NF-kB with immunomodulatory effects. And the latest researches have shown the involvement of A20 in the occurrence and development of various allergic diseases. This article reviews the origin, structure, and biological functions of A20 and its role in allergic asthma, through which new methods and ideas might be enlightened for the treatment and prevention of allergic asthma.