Pharmacokinetics and bioavailability of glucosamine after administration of glucosamine hydrochloride or glucosamine sulfate / 中国药理学通报

ABSTRACT

Aim: To determine the pharmacokinetics and bioavailability of glucosamine after administration of glucosamine hydrochloride (GH) and glucosamine sulfate (GS). Methods: GH or GS was given ig and iv to rats, respectively. An LC-MS/MS method was developed to measure the concentrations of glucosamine in plasma. DAS 3. 0 was employed to obtain the pharmacokinetical parameters as well as bioavailability. Results: There was no marked difference in T1/2, Vz and absolute availability between GH and GS. However, the relative bioavailability of GH was higher than that of GS. In addition, Tmax of GS was shorter than that of GH. Conclusion: There are some differences between the glucosamine pharmacokinetics of GH and GS.