Effect of yueju pill on depressive-like behavior and neurogenesis in corticosterone induced mice / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 283-288, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-857298
ABSTRACT
Aim:
To investigate the effects of Yueju pill on depressive-like behavior and neurogenesis in chronic corticosterone (CORT) induced mice.Methods:
Male C57BL/6N mice received chronic administration of CORT as well as Yueju pill. Behavioral tests were performed after the completion of treatment. The number of Ki67+ cells in the hippocampal DG region of each group was counted by immunohistochemistry test. Meanwhile, the expression levels of PKA, ERK and CREB were detected by Western blot.Results:
The sucrose preference notably decreased (P < 0. 05) in CORT-induced mice in SPT, and it was raised obviously after Yueju treatment. The TST and NSF test displayed the similar results. The immunohistochemistry showed that the number of Ki67+ cells in the hippocampus DG significantly decreased in CORT-induced mice, while the number of Yueju group apparently increased (P < 0. 05). Western blot showed that compared with control group, the protein expressions of PKA-ERK-CREB pathway were down-regulated in CORT-induced mice, which were up-regulated after Yueju treatment (P < 0. 05).Conclusions:
In CORT induced mice, Yueju pill can enhance the hippocampal neurogenesis by activating the PKA-ERK-CREB signaling pathway to display antidepressant-like effect.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
2019
Tipo de documento:
Artigo
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