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Regulation of lamin a/c in epigenetic pharmacology of stem cells / 中国药理学通报
Chinese Pharmacological Bulletin ; (12): 1-4, 2019.
Artigo em Chinês | WPRIM | ID: wpr-857300
ABSTRACT
Lamin A/C is I he main component of nuclear lamina, ami its important role of cpigenetie pharmacology in si em cells has been recognizcd in recent years, lmin A/C hus been reported to maintain the nuclear homeostasis, protect the chromatin, anil act as a reactor for mcchanical stimulation of the nucleus to transmit mechanical signals. Besides, Lamin A/C has been discovered to participate directly or indirectly in the transcriptional regulation of the genes. This article aims to review the regulation of Lamin A/C in stem cells by mechanical signals of microenvi- ronment, and live effect of Lamin A/C on chromosome modification and genes regulation.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Pharmacological Bulletin Ano de publicação: 2019 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Pharmacological Bulletin Ano de publicação: 2019 Tipo de documento: Artigo