A network pharmacology study on mechanism of tibetan medicine ryur dMar nyer inga ril bu against Alzheimer's disease / 中国药理学通报

ABSTRACT

Aim To investigate the underlying pharmacological mechanism of Tibetan medicine Byur dMar 25 (BM25) in the treatment of Alzheimer's disease(AD) based on network pharmacology approaches. Methods The potential target of the main blood components after oral administration of BM25 was predicted through reverse pharmacophore mapping scheme, and the main biological functions and cell signaling pathways were systematically analyzed based on bioinformatics strate-gies. Results BM25, as a multi-component drug with numerous potential targets may mainly participate in MAPK, insulin, mTOR signaling pathways, contributing to different biological functions including inflammation, apoptosis, and expression and clearance of beta amyloid ( A{3). Conclusion BM25 could interfere the progress of Alzheimer's disease, and the mechanism is a concerted pharmacological intervention of multiple components and targets.