FOXOs: Potential targets for treatment of heart diseases / 中国药理学通报

ABSTRACT

The high incidence and mortality of heart disease seriously affect human health. Among them, ischemic heart disease and myocardial hypertrophy are the most common. The transcription factor FOXOs can protect heart tissue by fighting oxidative stress and promoting apoptosis and autophagy, playing an important role in the treatment of heart disease. This article reviews the role of FOXOs in heart disease and signaling pathways. for the treatment of heart disease, FOXOs, as a potential target, provide new ideas for the treatment of heart disease.