The change of functions and hypermicro-instructure in lung in experimental aging mice and effect of cistanche desertica polysacchrides on the change / 中国药理学通报

ABSTRACT

AIM: To observe the alteration of the functions and hypermicro-instructure in lung of experimental aging mice and the effect of cistanche desertica polysacchrides on the alteration. METHODS: To use the models of inhaling ozone (O3) for 4 week, and two doses of cistanche desertica polysacchrides (50,100 mg·kg-1·d-1) were ig administrated to small and large dose group mice per day respectively (for 6 week). Then the behavioral and biochemical examinations of lung and blood was carried out, and the ultrastructures were observe by the transmission electronic microscopic. RESULTS: Compared with aging models, cistanche desertica polysacchrides could significantly prolong the period of nonoxygen (P< 0.01), promote SOD it also activity and decrease MDA contents in lung and serum respectively (P<0.01), it also could improve swelling of mitochondra and the alteration of multilamellar ultra-structure. CONCLUSION: Cistanche desertica polysacchrides improve the impaired physiological function and alleviate morphological change in lung in experimental aging mice.