The effects of TGP on CJ-S131-induced systemic lupus erythematosus -like model in mice / 中国药理学通报

ABSTRACT

AIM: To investigate the effects of TGP on immunologic changes associated with CJ-S131-induced SLE-like model in mice. METHODS: SLE-like syndrome was induced by injection of CJ-S131 and CFA. Various doses of TGP were given by gavage once daily for 28 days. RESULTS: The levels of IgG anti single-stranded DNA(ssDNA) and histone autoantibodies were increased in sera four weeks after injection. The proliferation response of splencytes to ConA and LPS and the production of IL-1 were also increased. TGP(50,100,200 mg·kg-1·d-1, ig) inhibited the aboved changes of SLE-like mouse model partly or completely. CONCLUSION: The SLE mouse model was similar to idiopathic SLE in humans. TGP has modulating effects on alternations of immunity of SLE-like mouse model.