The inhibitory effect of tamoxifen on the proliferation of the anterior pituitary cell of rats / 中国药理学通报

ABSTRACT

AIM: To investigate the effect of tamoxifen on the proliferation of the anterior pituitary cell of rats and its mechanism. METHODS: Primary culture of the anterior pituitary cell of rats and 3HTdR incorporation method were applied. The changes of cell morphology were observed directly by electric microscope. RESULTS: Tamoxifen could inhibit the proliferation of the anterior pituitary cell of rats. The inhibitory effect of tamoxifen (0.1 μmol·L-1) could be reversed by estrogen. The classical apoptotic changes appeared in the cells after tamoxifen incubation for 48 h. CONCLUSION: Tamoxifen can inhibit the proliferation of the anterior pituitary cell of rats and resultin the cell apoptosis.