Inhibitory effect of total flavones of Metasequsia glytostroboides on platelet aggregation and hemarheology in rats and mechanism research / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 214-217, 2002.
Article
em Zh
| WPRIM
| ID: wpr-857467
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WPRO
ABSTRACT
AIM: To observe the effects of total flavones of Metasequsia glytostroboides Hu et Cheng (FMG) on platelet aggregation, 5-HT release, NO contents of plasma and hemarheology in rats. METHODS: Platelet aggregation was quantified by turbidimetric method. 5-HT release was assayed by fluorescence technique. NO content of plasma was assayed by spectrophotometry. RESULTS: FMG inhibited the platelet aggregation and 5-HT release, increased the NO content of plasma, decreased the whole blood viscosity, plasma viscosity, eryrocyte electrophoresis time, K value of erythrocyte sedimentation equation and RBC, improved the hemarheology of rats. CONCLUSION: FMG can inhibit the platelet aggregation and improve the hemarheology in rats. The inhibition on 5-HT release, increase of NO contents of plasma and the inhibitory effect on Ca2+ may be its mechanisms.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
2002
Tipo de documento:
Article