Inhibitory effect of total flavones of Metasequsia glytostroboides on platelet aggregation and hemarheology in rats and mechanism research / 中国药理学通报

ABSTRACT

AIM: To observe the effects of total flavones of Metasequsia glytostroboides Hu et Cheng (FMG) on platelet aggregation, 5-HT release, NO contents of plasma and hemarheology in rats. METHODS: Platelet aggregation was quantified by turbidimetric method. 5-HT release was assayed by fluorescence technique. NO content of plasma was assayed by spectrophotometry. RESULTS: FMG inhibited the platelet aggregation and 5-HT release, increased the NO content of plasma, decreased the whole blood viscosity, plasma viscosity, eryrocyte electrophoresis time, K value of erythrocyte sedimentation equation and RBC, improved the hemarheology of rats. CONCLUSION: FMG can inhibit the platelet aggregation and improve the hemarheology in rats. The inhibition on 5-HT release, increase of NO contents of plasma and the inhibitory effect on Ca2+ may be its mechanisms.