Research progress in reactive oxygen species in tumorigenesis and tumor therapy / 中国药理学与毒理学杂志

ABSTRACT

Increased reactive oxygen species (ROS) cause oxidative and antioxidative imbalance in the body, which can damage biological macromolecules, such as DNA, and cause a variety of diseases including cancer. On the other hand, ROS plays an important role in tumor therapy. This paper reviews a variety of cancer-related signaling pathways associated with ROS, relationships between ROS and proliferation, migration, cell cycle and apoptosis of tumor cells and stem cells. Moreover, This paper reviewed the role of traditional anti-tumor drugs towards ROS and ROS responsing vectors in tumor therapy. It is expected to provide new ideas for cancer prevention and treatment.