Synthesis and Antitumor Activities of N-hydroxy-5-(3-substituted ureido)-1H-indole-2-carboxamide Derivatives / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1234-1242, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-857620
ABSTRACT
OBJECTIVE:
To design and synthesize N-hydroxy-5-(3-substituted urea)-1H-indole-2-amide derivatives and investigate their anti-tumor activity in vitro.METHODS:
A series of new N-hydroxy-5-(3-substituted ureido)-1H-indole-2-carboxamide derivatives (7a-7n)were designed and prepared from p-nitrophenylhydrazine and ethyl pyruvate. Their antitumor activities against Hela (breast cancer) lines, cervical cancer cell (MCF7) and human hepatoma cell lines (HepG2) were evaluated by methyl thiazolyl (MTT) method.RESULTS:
Target compounds indicated certain antitumor activities, especially compound 7h showed the strongest cytotoxicity to Hela cells with a half inhibition concentration (IC50) of 7.31 μmol•L-1.CONCLUSION:
The series of compounds show preferable antitumor activities, which are worthy of further study.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2020
Tipo de documento:
Artigo
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