Secondary Metabolites from a Fungus Beauveria felina SX-6-22 Sponge-Associated / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1853-1858, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-857852
ABSTRACT
OBJECTIVE:
To study the secondary metabolites of sponge-associated fungus Beauveria feline SX-6-22.METHODS:
The compounds were isolated and purified by silica gel, ODS reversed-phase column, preparative HPLC techniques. And their structures were identified by the physicochemical properties and NMR, MS data analysis. X-ray crystal diffraction was used to confirm the absolute configuration of compound1.RESULTS:
Nine secondary metabolites were isolated from the extract of the solid fermentation culture of strain SX-6-22, including four new compounds beauverins A-D (1-4) and five known compounds 1, 9-dimethyl-3, 7-dibenzofurandiol (5), diorcinol(6), cordyol C(7), mixture of violaceol (8) and violaceol Ⅱ(9). Compounds 5, 7, 8 and 9 showed strong antioxidant activity with IC50 (9.62±0.12), (11.11±0.02), and (8.44±0.08) μg•mL-1 by DPPH assay.CONCLUSION:
Four new compounds and three antioxidant known compounds are isolated from sponge-associated fungus SX-6-22.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2019
Tipo de documento:
Artigo
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