Optimization of Preparation Process of Fast-Dissolving Microneedles by Box-Behnken Method / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1677-1684, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-857881
ABSTRACT
OBJECTIVE:
To optimize the formulation and preparation process of fast-dissolving PVP microneedles, and provide a high-quality carrier for PVP drug-loaded microneedle research.METHODS:
On the basis of single factor, the needle tips dissolution time and insertion ratio were used as the evaluation indexes, and the optimal preparation process of microneedle was optimized by Box-Behnken method.RESULTS:
From the single factor test and the Box-Behnken test, it was known that the optimum preparation conditions were as follows the needle tip concentration was 0.70 g•mL-1, the temperature was 40 ℃, and the humidity was 40%. The microneedle height was 600 μm, the width was 200 μm, the pitch was 500 μm, quadrangular pyramid. The area of the microneedle patch was 0.56 cm2, the dissolution time in water was (41.00±3.74)s, and the insertion ratio was (93.19±5.25)%.CONCLUSION:
The PVP fast-dissolving microneedles can be prepared simply and conveniently by the Box-Behnken method, which provides a reference for the preparation of further drug-loaded microneedles.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2019
Tipo de documento:
Artigo
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