Acute Pancreatitis Induced by Azathioprine and 6-mercaptopurine Proven by Single and Low Dose Challenge Testing in a Child with Crohn Disease / 대한소아소화기영양학회지
Pediatric Gastroenterology, Hepatology & Nutrition
;
: 272-275, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-85804
ABSTRACT
We report here a case of drug-induced acute pancreatitis proved by elimination and single, low dose challenge test in a child with Crohn disease. A 14-year-old boy with moderate/severe Crohn disease was admitted due to high fever and severe epigastric pain during administration of mesalazine and azathioprine. Blood test and abdominal ultrasonography revealed acute pancreatitis. After discontinuance of the medication and supportive care, the symptoms and laboratory findings improved. A single, low dose challenge test was done to confirm the relationship of the adverse drug reaction and acute pancreatitis, and to discriminate the responsible drug. Azathioprine and 6-mercaptopurine showed positive responses, and mesalazine showed a negative response. We introduce the method of single, low dose challenge test and its interpretation for drug-induced pancreatitis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pancreatite
/
Azatioprina
/
Doenças Inflamatórias Intestinais
/
Doença de Crohn
/
Mesalamina
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Febre
/
Testes Hematológicos
/
Mercaptopurina
Limite:
Criança
/
Humanos
Idioma:
Inglês
Revista:
Pediatric Gastroenterology, Hepatology & Nutrition
Ano de publicação:
2012
Tipo de documento:
Artigo
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