Preparation and Characterization of Naringenin Nicotinamide Co-crystal / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 291-296, 2019.
Article
em Zh
| WPRIM
| ID: wpr-858068
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: To prepare a novel naringenin co-crystal to improve the poor water solubility of the compound. METHODS: Solvent volatilization method was used to prepare naringenin nicotinamide co-crystal, with ethyl acetate as solvent. It is characterized by the technology of infrared spectroscopy (IR), differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), scanning electron microscopy (SEM) and other techniques. RESULTS: By measuring the equilibrium solubility of different pH solutions, it was found that the naringenin nicotinamide co-crystal has a significantly improved equilibrium solubility compared with naringenin. CONCLUSION: This method can improve the solubility of naringenin, which is simple and easy, and lays the foundation for further study of naringenin co-crystal.
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WPRIM
Idioma:
Zh
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2019
Tipo de documento:
Article