The Chemical Constituents Study of Naoxintong Capsules Based on UHPLC-Q-Orbitrap HRMS / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1687-1695, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-858201
ABSTRACT
OBJECTIVE:
To establish a novel ultra-high performance liquid chromatography-quadrupole/orbitrap high resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) method to study the chemical composition of Naoxintong capsules rapidly and accurately.METHODS:
The information of accurate mass in full-MS and multistage fragment ions was obtained by the novel UHPLC-Q-Orbitrap technology. Chemical constituents were identified by comparing the relative retention time and the mass data of the reference substances, meanwhile consulting the reference literature or the Mass Bank, Chemical Book network database.RESULTS:
Forty-four compounds were finally identified in this study, mainly including flavones, authraquinones, terpenoids and organic acids.CONCLUSION:
A method is established in this study to identify various chemical constituents of Naoxintong capsules rapidly, accurately and systematically. What's more, our research will lay a sound theoretical foundation and propose a scientific study idea for the quality control improvement, bioactive components recognition and further clinical application of this herbal formulation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2018
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS