Chemical Constituents in Flowers of Paulownia fortunei(Seem.) Hemsl / 中国药学杂志

ABSTRACT

OBJECTIVE: To investigate the chemical constituents in flowers of Paulownia fortunei (Seem.) Hemsl. METHODS: The flowers of Paulownia fortunei (Seem.) Hemsl. Were extracted with 50% aqueous acetone by tissue disruption extraction. The compounds were isolated and purified by Diaion HP-20, Toyopearl HW-40, Sephadex LH-20, MCI Gel CHP-20, silica gel column chromatography and preparative HPLC, and their structures were elucidated on the basis of spectral data and physiochemical properties. RESULTS: Nineteen compounds were elucidated as 2-(3-methoxy-4-hydroxyphenyl)-propane-1,3-diol(1), 1-phenylpropane-1,2,3-triol(2), 3,4-dihydroxy-β-methoxyphenethy alcohol(3), chryseriol(4), phenylpropanoid(5), apigenin(6), luteolin(7), 4-hydroxy-3-methoxybenzoic acid(8), 2-(4-hydroxyphenyl) ethanol(9), 3,4-dihydroxyphenylethyl alcohol(10), vanillic acid(11), 3-(4-hydroxy-3,5-dimethoxyphenyl) propane-1,2-diol(12), p-hydroxybenzoic acid(13), astragalin(14), nicotinic acid(15), thymidine(16), thymine(17), 5-(4′-hydroxybenzyl) hydantoin(18) and 1-(3-indolyl)-2,3-dihydroxypropan-1-one(19). CONCLUSION: Compounds 1-3, 5, 8-10, 12, 14-19 are isolated from this plant for the first time.