Preparation of Montelukast Sodium Orally Disintegrating Tablets and Study on the Bioequivalence in Beagle Dogs / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 1088-1092, 2018.
Article
em Zh
| WPRIM
| ID: wpr-858286
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WPRO
ABSTRACT
OBJECTIVE: To prepare montelukast sodium orally disintegrating tablets and investigate the bioequivalence in Beagle dogs. METHODS: The orally disintegrating tablets were prepared by direct compression method,and the optimal formulation was screened by orthogonal test.HPLC-fluorescence method was developed for determination of montelukast sodium plasma concentration in Beagle dogs. RESULTS: The optimized formulation(1 000 tablets) was montelukast sodium 10.4 g, microcrystalline cellulose 60 g, cross linked povidone 30 g, mannitol 15 g, magnesium stearate 2 g, aerosil 1 g, aspartame 1 g, flavor 0.6 g. CONCLUSION: Montelukast sodium orally disintegrating tablets made of the optimized formulation could disintegrate rapidly. Relatively bioavailability of montelukast sodium orally disintegrating tablets is 90.7%.
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WPRIM
Idioma:
Zh
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2018
Tipo de documento:
Article