Population Pharmacokinetics of Isoniazid in Chinese Tuberculosis Patients / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 2185-2191, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-858482
ABSTRACT
OBJECTIVE:
To characterize the population pharmacokinetics of isoniazid in Chinese tuberculosis patients.METHODS:
A total of 321 serum samples were obtained from 201 patients receiving oral doses of isoniazid. The effects of 16 covariates including demographics and blood tests to isoniazid's pharmacokinetics were evaluated. Data analysis was performed using non-linear mixed effects modeling (NONMEM). Prediction-corrected visual prediction check was performed for model evaluation.RESULTS:
A two-compartment model with first-order absorption and linear elimination can well fit the isoniazid concentration-time data. A "MIXTURE" model was used to separate the subpopulation of 'subgroup A' and 'subgroup B'. Typical clearance of the two subpopulations were 82.7 and 19.3 L·h-1, respectively.CONCLUSION:
Model validation shows the final model is reliable, which could be used for individualized treatment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2017
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS