Preparation of Aspirin Sustained Release Pellets Using Stearic Acid and Microcrystalline Cellulose / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 2098-2103, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-858496
ABSTRACT
OBJECTIVE:
To evaluate microcrystalline cellulose(MCC) and stearic acid(SA) on extrusion-spheronisation(E-S) for aspirin sustained release pellets.METHODS:
Mixtures with varying drug concentration and SA/MCC ratios were processed via non-aqueous E-S. Multi-index evaluation method were assessed by rheological behavious, drug stability and release in vitro compared with aqueous E-S.RESULTS:
The extrusion was easier when SA/MCC was > 35%. When the ratio of SA/MCC was about 1, the roll effect was the best. The drug content was 65%. Compared with aqueous E-S, non-aqueous E-S was small and homogeneous pellets, better apparent characteristics, stability. There were no obvious different in drug release in vitro.CONCLUSION:
These prove to be superior aids for water sensitive aspirin when exposed to non-aqueous solvent by E-S.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2017
Tipo de documento:
Artigo
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