Preparation and Quality Evaluation of Avilamycin Self-emulsifying Microemulsion / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1848-1854, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-858548
ABSTRACT
OBJECTIVE:
To optimize the formulation of avilamycin self-microemulsifying drug delivery system (SMEDDS) using central composite design-response surface method and evaluate its quality.METHODS:
The compositions of avilamycin SMEDDS were screened by solubility experiment and self-emulsifying grading test. The formulation was optimized using Design Expert Software, taking particle size and Zeta potential as dependent variables and the usage amounts of oil, surfactant and cosurfactant as independent variables.RESULTS:
The optimized formulation was quickly and conveniently obtained as follows 36.67% propylene glycollaurate, 42.83% cremophor RH40 and 20.50% diethylene glycol monoethyl ether.The average diameter of the preparation was (28.34±0.06)nm, the Zeta potential was (-1.98±0.24)mV and PDI was (0.15±0.005).CONCLUSION:
The central composite design and response surface method is useful for the formula optimization of avilamycin self-microemulsifying drug delivery system.The prediction accuracy of the established mode1 is good.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2017
Tipo de documento:
Artigo
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