Preliminary Study on Stability and Pharmacokinetics of Chitosan-Modified L-asparaginase Liposomes / 中国药学杂志

ABSTRACT

OBJECTIVE: To investigate the stability and pharmacokinetics of chitosan-modified L-asparaginase liposomes. METHODS: The activities of L-asparaginase and chitosan-modified L-asparaginase liposomes in blank rat plasma were determined at different time. L-asparaginase and chitosan-modified L-asparaginase liposomes were intravenously injected to rats through tail vein. The pharmacokinetic parameters were calculated by DAS. RESULTS: The activity of chitosan-modified L-asparaginase liposomes in plasma was significantly higher than that of L-asparaginase. The AUC0-48 h of chitosan-modified L-asparaginase liposomes was as 3.3 times as that of L-asparaginase. And the MRT0-48 h of chitosan-modified L-asparaginase liposomes was as 2.3 times as that of L-asparaginase. CONCLUSION: Chitosan-modified L-asparaginase liposomes can improve the stability and bioavailability of L-asparaginase.