Summary of Small Molecular Bitter Quenchers are Applied to Oral Liquid Preparations / 中国药学杂志

ABSTRACT

Bitter drugs in oral liquid preparations are mostly in the form of molecule or colloid, which can instantly form a broad and strong stimulation with the large dispersion. Therefore, it makes the traditional bitter-masking method difficult to completely mask the bitterness, and greatly restrict the compliance of patients. In recent years, the discovery of small molecular bitter quenchers (SMBQ)has provided a new choice for improving the taste of oral liquid and has gradually become a hotspot in the research of bitter-masking technology. Based on these reasons, the paper explained the concept and characteristics of SMBQ, summarized the mechanism and influencing factors of bitterness quenching, and introduced the commonly-used small bitter quench quencher and its characteristics and applications. This study was aimed to promote the development and application of SMBQ in oral liquid preparations, and provide scientific theoretical guidance and technical support for bitter masking of oral liquid preparations. It may be of great theoretical and practical significance to promote the solution of the practical problems of oral liquid, the optimization of prescription design, and the improvement of product quality.