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Excipient Formula Research of Nicotinate-Curcumin nanoparticles Prepared by Film Ultrasonic Method / 中国药学杂志
Chinese Pharmaceutical Journal ; (24): 462-467, 2017.
Artigo em Chinês | WPRIM | ID: wpr-858774
ABSTRACT

OBJECTIVE:

To optimize the film-ultrasonic technique for preparing nicotinate-curcumin nanoparticles.

METHODS:

An HPLC method was established for determination of nicotinate-curcumin. Using the entrapment efficiency of nicotinate-curcumin as the evaluation indicator, the optimum excipient formula was selected through the Box-Bebnken reponse surface design of three factors (amounts of nicotinate-curcumin and lecithin and concentration of tween-80) at three levels.

RESULTS:

With the established optimal formula, ie 80 mg stearic acid, 150 mg lecithin and 20 mL tween-80 (0.6%), the entrapment efficiency of nicotinate-curcumin approached 65%. The mean particle size was 190 nm.

CONCLUSION:

The nicotinate-curcumin nanoparticles prepared by the film ultrasonic technique optimized by central composite design test have high entrapment efficiency, indicating that the technique is feasible.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Pharmaceutical Journal Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Pharmaceutical Journal Ano de publicação: 2017 Tipo de documento: Artigo