Application of TOPSIS Comprehensive Evaluation Method in Preparation of Xiaoerjianpiwentong Plaster / 中国药学杂志

ABSTRACT

OBJECTIVE: To screen the preparation technology of Xiaoerjianpiwentong plaster using the technique for order preference by similarity to ideal solution (TOPSIS) comprehensive evaluation method. METHODS: Using color, uniformity, adhesive ability, and peeling strength as the quality control indexes with different weighting factors, plasters of different prescriptions were scored by the TOPSIS comprehensive evaluation method. Experiments were conducted to repeat eight representative literatures to select the matrix and preparation process for the gel plaster. Single factor experiment was performed in combination with TOPSIS comprehensive evaluation method to select the best composition of prescription, and verification tests were conducted. RESULTS: The best prescription of Xiaoerjianpiwentong plaster was as follows gelatin-polyvinyl pyrrolidone K30(PVP K30)-sodium polyacrylate-glycerol-laurocapram-extract powder-volatile oil=212.512110.234(m/m). CONCLUSION: The best composition of prescription of Xiaoerjianpiwentong plaster is determined. The plaster not only has good appearance and peeling strength, but also has stable quality and formability.