Identification of related substances in a new drug aituomode by HPLC-MS/MS / 中国药学杂志

ABSTRACT

OBJECTIVE: To identify the related substances in aituomode bulk drug. METHODS: HPLC-QTrap-MS and HPLCQTOF-MS were used to determine seven kinds of related substances denoted by Imp-A to Imp-G. RESULTS: The structures and molecular weights of the related substances in aituomode were identified. CONCLUSION: The method is simple and accurate, providing a good idea for the identification of the related substances in bulk drugs. The experimental data are valuable to the determination of the related substances and quality control of aituomode.