Single nucleotide polymorphisms analysis of drug related genes in digestive tract cancer / 中国药学杂志

ABSTRACT

OBJECTIVE: To analyze of the characteristics of single nucleotide polymorphisms of the commonantineoplastics in the treatment of gastric cancer and colorectal cancer in our hospital. METHODS: Venous blood was collected from patients with digestive tract tumor, and the drug related gene loci were detected by fluorescence staining in situ hybridization. The original data are stored in Microsoft Excel to establish a database for routine statistics and chi square test was conducted to determine whether the distribution of allele frequency distribution is in accordance with the law of Hardy Weinberg. RESULTS: A Total of 1 743 loci of 14 drug related genes were detected in 242 patients. The loci genotype distribution were in accordance with Hardy Weinberg equilibrium except dihydrotestosterone dihydropyrimidine dehydrogenase gene (DPYD), methylenetetrahydrofolate reductase gene (MTHFR) and cytochrome P4501B1 gene (CYP1B1). CONCLUSION: The patients with digestive tract tumor in China have their own characteristics in single nucleotide polymorphisms of drug related genes. We should take this as the basis for accurate anti-tumor drug treatment.