Preparation and transdermal permeation of ropivacaine ethosomal gel in vitro / 中国药学杂志

ABSTRACT

OBJECTIVE: To prepare ropivacaine ethosomal gel and study its transdermal permeation. METHODS: The ropivacaine ethosomes were prepared by ethanol injection method. The formulation and the preparation method of ethosomes were optimized by orthogonal experiment. The particle size, morphology and encapsulation efficiency were evaluated, and the carbomer was added as the base for the preparation of the ethosomal gel. The penetration experiments of ropivacaine ethosomal gel through mouse skin were performed by Franz's cell. The cumulative penetration amount was calculated. RESULTS: The obtained ethosomes were approximately spherical, the size were (127.6±4.8) nm. The entrapment efficiency of ropivacaine in ethosomes was (77.58±1.07)%. Accumulative permeation amount of ropivacaine ethosomal gel within 24 h was 73.07 μg·cm-2, which was about 1.56 times of normal gel. CONCLUSION: The gel is feasible in preparation technique, controllable in quality and can significantly promote transdermal penetration of ropivacaine.