Synthesis and antioxidative activities of flavone derivatives containing dihydropyrazole moiety / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1643-1647, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-858951
ABSTRACT
OBJECTIVE:
To design and synthesize flavone derivatives containing dihydropyrazole moiety and investigate their antioxidative activities in vitro.METHODS:
7-Bromoethoxy flavone was synthesized by the reaction of 7-hydroxy flavone with 1, 2-dibromoethane. Then six flavone derivatives containing dihydropyrazole moiety were synthesized by the condensation reaction of 7-bromoethoxy flavone with two types of O-phenyl substituted dihydropyrazole compounds. These new compounds were characterized by IR, 1H-NMR, 13C-NMR, ESI-MS and EA. Their antioxidation effects, such as scavenging effects on the superoxide radical (O2-), hydroxyl radical (·OH), DPPH· radical, nitroso radicals (NO2·) and the total reduction activities, were compared.RESULTS:
At the concentration of 0.5 mg·mL-1 most of the title compounds had antioxidation effects, but their activities were weaker than that of vitamine C.CONCLUSION:
The scavenging effects on four different radicals and the total reduction activity of 7-(1-phenyl-3-methyl-4, 5-dihydropyrazole-5-phenyl)-oxyethoxy flavone (compound 2a) are all relatively strong. Its antioxidative activities in vivo can be further investigated.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2016
Tipo de documento:
Artigo
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