Content determination of dutasteride and antioxidant butylated hydroxy toluene in dutasteride soft capsules by HPLC / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1592-1595, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-858974
ABSTRACT
OBJECTIVE:
To establish a high performance liquid chromatography method to determine the contents of dutasteride soft capsules.METHODS:
The chromatographic analysis was performed on a Phenomenex C18(Luna,4.6 mm × 150 mm, 3.0μm) column. The mobile phase was gradiently eluted. The flow rate was 1.0 mL < min-1. The detection wavelength was set at 240 and 285 nm, and the injection volume was 50 μLRESULTS:
The linear ranges of dutasteride and butylated hydroxy Toluene (BHT) were 9.785-36.693 and 0.679-2.545 μg< mL-1, and the recoveries of this method were 99.9% and 102% with RSDs of 0.9% and 3.6%, respectively.CONCLUSION:
This assay is proved to be simple, specific, and accurate. It can be effectively applied in the quality control of dutasteride soft capsules.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2016
Tipo de documento:
Artigo
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