Recent advances in inorganic materials-based nanoparticles to overcome multidrug resistance of cancer cells / 中国药学杂志

ABSTRACT

Multidrug resistance (MDR) is one of the major obstacles for successful chemotherapy in cancer. Inorganic material-based nanoparticles provide a novel choice to effectively circumvent the intrinsic drawbacks of traditional organic materials in overcoming the multidrug resistance (MDR) of cancer cells due to their unique structural and compositional characteristics, for example, high stability, large surface area, tunable compositions, abundant physicochemical multifunctionalities, and specific biological behaviors. In this work, the recent advances of inorganic materials-based nanoparticles to overcome MDR of cancer cells were reviewed. And the advantage and mechanism of inorganic materials-based nanoparticles to overcome MDR were summarized. The recent development of inorganic materials-based nanoparticles (mesoporous SiO2, Au, TiO2, magnetic Fe3O4, Ag, combinations of inorganic materials-based nanoparticles with traditional overcoming MDR strategy etc.), to overcome the MDR were also discussed. And the future developments of these inorganic materials-based nanoparticles are suggested. These elaborately designed inorganic materials-based nanoparticles offer an unprecedented opportunity and show the encouraging bright future for overcoming the MDR of tumors.