Multifunctional gold nanoshell-coated magnetic nanoparticles: preparation, characterization, two-photon optical properties and drug release exploration / 中国药学杂志

ABSTRACT

OBJECTIVE: To prepare a kind of novel multifunctional gold nanoshell coated magnetic nanoparticles and investigate their morphology, size distribution, two-photon optical properties, cellular uptake behavior, cytotoxicity as well as drug release profile. METHODS: In this study, the gold shell coated magnetic polyester nanoparticles (AuMPn) were prepared by emulsion solvent evaporation method combined with hydroxylamine reduction method. The size distribution, morphology, and two-photon optical properties were characterized by Zeta sizer, AFM, TEM and multiphoton confocal laser scanning microscopy respectively. The drug loading and release profile were evaluated by dialysis method using idarubicin as a model drug. RESULTS: The resultant AuMPn exhibit spherical shaped morphology with average size of (235.7±1.34) nm. The encapsulation efficiency and drug loading efficiency were 72.08% and 1.73% respectively. Under near infrared light irradiation, gold shell outside of AuMPn showed fingerprint like characteristic emission spectrum. The in vitro drug release study demonstrated that the release of idarubicin from AuMPn can be controlled by NIR irradiation. CONCLUSION: Overall, a novel gold shell coated nanoparticles are successfully prepared in this study. By taking advantage of the dual function of the gold shell outside of the particles, precise control on drug release as well as label-free visualization of AuMPn can be achieved simultaneously. Thus, this approach provides a new strategy for drug delivery.