Preparation and quality evaluation of enramycin self-microemulsifying drug delivery system / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1235-1240, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-859045
ABSTRACT
OBJECTIVE:
To prepare enramycin self-microemulsifying drug delivery system (SMEDDS) and evaluate its quality.METHODS:
The formulations of enramycin SMEDDS were screened by solubility experiment and self-emulsifying grading test. The formulation was optimized using Design Expert Software, taking particle size as dependent variable and the usage amoumts of oil, surfactant, and cosurfactant as independent variables.RESULTS:
The optimized formulation of enramycin SMEDDS consisted of 20% ethyl oleate, 40% RH40, and 40% 1,2-propylene glycol. 1.0 g mixture contained 20 mg enramycin, which dispersed rapidly into water and the particle size of the formed emulsion was (27.81±0.79)nm. The enramycin SMEDDS dissolved by more than 90% within 10 min, much faster than that of enramycin API. The particle size and concentration of SMEDDS were stable at alternative temperature cycles (4 and 40℃) for 48 h, and the SMEDDS formulation had no effect on the bacteriostasis of enramycin.CONCLUSION:
The quality of enramycin SMEDDS is stable. The system increases the dissolution of enramycin significantly and could be advantageous to improve the oral bioavailability of enramycin.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2016
Tipo de documento:
Artigo
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