Analysis of vancomycin's blood concentration monitoring and effects of renal functions in critical pa-tients / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the relativity between patients' blood concentration of vancomycin and renal function, provide references for rational clinical application. METHODS: The blood concentration and renal function of 64 cases of critical patients were monitored after the usage of vancomycin, then retrospectively analyzed combined with clinical date (basic information, bacteriological results, clinical curative effect, etc.). RESULTS: Pathogenic bacteria was detected from 40 of 64 patients, accounting for 62.5%. The effective rate of vancomycin reached 81.25%. The average value of 79 monitered cases of valley concentration was (17.48± 13.22) μg ·mL-1. There was no significant difference of the level of BUN and Scr before and after the treatment of vancomycin, while the level of Ccr had the significant difference. There were significant difference of the level of BUN, Scr, Ccr between the groups of valley concentration 20 μg· mL-1. CONCLUSION: The application of vancomycin in critical patients is relatively cautions. When using the drug, the drug concentration and renal function can be adjusted according to the results of blood concentration and renal function.