Impurity profile study of cloxacillin sodium for injection / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 488-493, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-859177
ABSTRACT
OBJECTIVE:
To investigate the impurity profile of cloxacillin sodium for injection and study the source of major impurities.METHODS:
The impurities in samples from seven manufacturers were profiled by an optimized reversed-phase HPLC method and a newly established normal-phase HPLC method. The major impurities were prepared by semi preparation technology and identified by LC-QTOF-MS, 1H-NMR and 13C-NMR.RESULTS:
Two new impurities relating with the salt-forming reaction and the purification process respectively, and four other new impurities were all successfully identified in this study.CONCLUSION:
The study is suitable for profiling the impurities in cloxacillin sodium for injection and is quite useful for enhancing the quality control.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2016
Tipo de documento:
Artigo
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