The stability study of vitamin c tablets made by automatic dispensing machine in working mode / 中国药学杂志

ABSTRACT

OBJECTIVE: To observe the stability status of vitamin C tablets which are made by the dispensing machine in working mode and try to find out the procedures which may bring some potential hazards in the new modes. METHODS: According to the Pharmacopoeia the procedures were detected and collected data of the Vitamin C Tablets were made by dispensing machine in existing working mode. The data is collected from different aspects, including the color of drug solution, pharmic content, microbial limit from the storage and dispensing process. Then we compare these data with the factory's report and analyse the differences. RESULTS: There is no significant difference between the data we get and the factory's report of vitamin C tablets made by the dispensing machine in working mode, including the color of drug solution, pharmic content and the appearance of tablets. But there is an increasing trend of bacterial colonies in microbial limit tests for the two samples. CONCLUSION: The status of vitamin C tablets made by dispensing machine in working mode is generally stable. The increasing number of bacterial colonies shows that the time when drugs are exposed in the air, the cleanliness of dispensing environment and pharmaceutical package material are the key for drug quality control.