Advances in anti-influenza virus of neuraminidase inhibitors / 中国药学杂志

ABSTRACT

Neuraminidase (NA) is a mushroom-shaped and tetramer structural envelope glycoprotein on the surface of the influenza virus. NA inhibitors can inhibit highly pathogenic influenza virus subtypes and have good safety and drug resistance, hence they are widely used for the prevention and treatment of influenza virus. Based on the present domestic and foreign literatures in this field, this paper summarizes the research status of neuraminidase inhibitors classification and structure-activity relationships. It will help us make better use of existing conditions to design and synthesize better active and more selective anti-influenza drugs.