Glucolipid metabolism and antioxidant effect of the total flavones of propolis in GK rats / 中国药学杂志

ABSTRACT

OBJECTIVE: To study on glucolipid metabolism effect of the total flavones of propolis (TFP) in Goto-Kakisaki rats (GK Rats). METHODS: Fifty GK rats were randomly divided into 5 groups by blood glucose, the model group, positive drug group (2 000 mg · kg-1) and the high (240 mg · kg-1) dose of the TFP group, the medium (120 mg · kg-1) doses of the TFP group, low (60 mg · kg-1) doses of the TFP group. The GK rats in TFP groups were given with TFP by intragastric administration, continuously treated for 8 weeks, the control group were given equal sodium carboxymethylcellulose(CMC-Na) and positive drug group were given (2 000 mg · kg-1) dose of Xiaoke pills by intragastric administration. The glucose (Glu), total cholesterol (TC), triglyceride (TG), high density lipoprotein(HDL-C), low density lipoprotein(LDL-C), glycated hemoglobin(GHb), superoxide dismutase (SOD), ma-londialdehyde(MDA), glutathione(GSH), serum insulin(lNS), C-peptide(C-P), tumor necrosis factor-α(TNF-α) free fatty acid (FFA), nitric oxide(NO), and hepatic glycogen were measured at the end of the experiment. RESULTS: Compared with the control group, the levels of GLU, TG, TC, LDL-C, GHb, MDA and TNF-α were decreased significantly (P 0.05) in the low-dose group. The levels of SOD, hepatic glycogen, NO and C-P were increased significantly(P < 0.05 or P < 0.01), the levels of GLU, MDA, TG and GHb were decreased significantly (P < 0.05 or P < 0.01 or P < 0.001) in Xiaoke pills group. CONCLUSION: TFP can significantly decrease the level of blood glucose, significantly improve the glucose and lipid metabolism and inhibit insulin resistance in deficiency of GK rats.