In vitro antibacterial activity of colistin in combination with other antibacterials against the 73 strains of multidrug-resistant acinetobacter baumannii / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 427-430, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-859386
ABSTRACT
OBJECTIVE:
To evaluate the antibiotic effects in vitro of colistin combined with other antibacterials respectively against 73 strains of multidrug-resistant Acinetobacter baumannii (MDR-Ab).METHODS:
The protocol was designed by checkerboard method and the MICs of drugs alone and combination against the 73 strains of Acinetobacter baumannii were determined by broth dilution method, the FIC index was calculated according to MIC results. The interaction was measured by the fractional inhibitory concentration index (FIC) antagonism was defined as FICI≥4, indifference as 1CONCLUSION:
The results suggested that synergism and partially synergism and addition of colistin combined with minocycline and fosfomycin respectively against 73 strains of Acinetobacter baumannii were main action, there are little indifference and no antagonism.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2015
Tipo de documento:
Artigo
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