Identification of a metal ion-induced degradation impurity in huperzine A injection / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 634-638, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-859408
ABSTRACT
OBJECTIVE:
To identify the structure of an impurity of huperzine A injection.METHODS:
HPLC-QTOF-MS was adopted to analyze the structure of the impurity, which was further isolated and prepared by prep-HPLC and the structure was established on the basis of spectroscopic data.RESULTS:
The impurity was elucidated as (111E)-7,8-dichloro-5-amino-11-ethylidene-7-methyl-5,8,9,10-tetrahydro-5,9-methenecyclooctatriene [b] pyridin-2(1H)-one.CONCLUSION:
The impurity was deduced as a metal ion-induced degradation product. This investigation provides reference for the improvement of quality control and process optimization of huperzine A injection.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2015
Tipo de documento:
Artigo
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