Chemical constituents from swertia cincta burk. and their antagonistic effects on benign prostatic hyperplasia / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 502-506, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-859419
ABSTRACT
OBJECTIVE:
To study the chemical constituents extracted from the whole plants of Swertia cincta Burk. and their antagonistic effects on benign prostatic hyperplasia (BPH).METHODS:
The compounds were isolated by various chromatographic methods including silica gel, reverse silica gel, RP-HPLC, Sephadex LH-20, preparative TLC, and so on. Their structures were i-dentified by extensive analysis of the spectroscopic data. Experimental prostatic hyperplasia was produced in male Sprague-Dawley (SD) rats by testosterone injection for 28d, and then the prostate index(PI) was measured.RESULTS:
Eleven compounds were isolated from the whole plants of Swertia cincta Burk. and identified as swertiamarin(1), (R)-(-)-gentiopicroside(2), sweroside(3), 6'-O-β-D-glucopyranosylsweroside(4), 6'-O-β-Z)-glucopyranosylgentiopicroside(5), loganic acid(6), oleanolic acid(7), 2α, 3β-dihydroxyolean-12-en-28-oicacid-28-O-β-D-glucopyranoside (8), β-daucosterol (9), 4-hydroxyl-3, 5-dimethoxyl-6-O-β-D-glu-cosebenzene(10), and isoorientin (11). Swertiamarin significantly decreased PI in SD rats.CONCLUSION:
Compounds 5 and 8 were isolated irom the plants of Swertia cincta for the first time. Compound 1 has favorable effect for inhibiting prostatic hyperplasia in SD rats.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2015
Tipo de documento:
Artigo
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