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Effects of pH on the suspension gel formation and free aluminum ions of sucralfate / 中国药学杂志
Chinese Pharmaceutical Journal ; (24): 965-967, 2015.
Artigo em Chinês | WPRIM | ID: wpr-859527
ABSTRACT

OBJECTIVE:

To investigate the effect of antacids on the efficacy and safety of sucralfate.

METHODS:

The appearance of sucralfate suspension gel was observed under different pHs in vitro to learn the appropriate pH for sucralfate to work. The adverse effects of sucralfate was evaluated by determining the aluminum ion concentration in the supernatant using emission spectrometry with inductively coupled plasma (ICP-OES).

RESULTS:

At pH 0.1, sucralfate was partly dissolved; at pH 1.0 and 2.0, it formed white soft gel with strong adhesion and good extension; along with the storage time, the gel gradually precipitated; at pH≥3, sucralfate was unable to form gel; at pH >4.0, it formed a hard white precipitate without obvious adhesion and spreadability. In the pH range of 0.1-7.0, the concentration of free aluminum ion reduced gradually with the increase of pH.

CONCLUSION:

Combination use of antacids with sucralfate does not increase the aluminum ion absorption, but whether there is a synergistic effec is worth of further exploration.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Pharmaceutical Journal Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Pharmaceutical Journal Ano de publicação: 2015 Tipo de documento: Artigo