Clinical research progress of anti-proprotein convertase subtilisin/kexin type 9 (pcsk9) monoclonal antibodies / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1375-1379, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-859590
ABSTRACT
To summarize the data from clinical trials of anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies (mAbs) in patients with hypercholesterolaemia. Based on systematic literature review, theresults of clinical trials of different anti-PCSK9 mAbs were presented and evaluated. In phase I, II, III trials, anti-PCSK9 mAbs resulted in 50%-60% reduction in low-density lipoprotein-cholesterol (LDL-C) level and had a lower incidence of adverse effects, compared with placebo or ezetimibein patients with hypercholesterolaemia. Anti-PCSK9 mAbs have demonstrated a significant effect of reducing LDL-C and were well tolerated in short-term (up to 52 weeks) trials. Large phase III trials are ongoing to evaluate the long-term safety and efficacy as well as the impact of these promising new agents on cardiovascular outcomes.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2015
Tipo de documento:
Artigo
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