Chemical constituents of Artemisa sacrorum ledeb / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the chemical constituents of the chloroform extract from the aerial parts of Artemisa sacrorum. METHODS: The chemical constituents were isolated and purified by silica gel and LH-20 column chromatography and preparation HPLC. Their structures were identified by spectral analysis methods. RESULTS: Thirteen compounds were obtained and identified as 5-hydroxyl-7, 4'-dimethoxyflavone(1), 4-hydroxylacetophenone(2), 5, 4'-dihydroxyl-7, 3'-dimethoxyflavone(3), 5, 7-dihydroxyl-6, 4'-dimethoxyflavone(4), 5, 7-dihydroxyl-6, 4'-methoxyflavone(5), 5, 4'-dihydroxyl-7-methoxyflavone(6), caffeic acid(7), 8-hydroxyl-6, 7-dimethoxycoumarin(8), 3, 4-dihydroxylbenzoic acid (9), acetophenone-4-O-β-D-glucoside(10), 6-methoxycoumarin-7-O-β-D-glucoside(11), 6, 8-dimethoxycoumarin-7-O-β-D-glucoside(12), and 2-hydroxyl-6-methoxyacetophenone-4-O-β-D-glueoside(13). CONCLUSION: Compounds 3, 4, 5, 9, 10 and 12 are isolated from this plant for the first time.