The role of spinal adrenergic receptors on the antinociception of ginsenosides in a rat postoperative pain model / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 55-60, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-85960
ABSTRACT
BACKGROUND:
The effect of spinal adrenergic and cholinergic receptors on the anti-nociceptive effect of intrathecal ginsenosides was determined in a rat postoperative pain model.METHODS:
Catheters were placed into the intrathecal space of male Sprague-Dawley rats. Postoperative pain was evoked by an incision to the plantar surface of a hind paw. Withdrawal thresholds was used as a nociceptive parameter and was measured with a von Frey filament. After observing the effect of intrathecal ginsenosides, an alpha-1 adrenergic receptor antagonist (prazosin), an alpha-2 adrenergic receptor antagonist (yohimbine), a muscarinic acetylcholine receptor antagonist (atropine), and a nicotinic acetylcholine receptor antagonist (mecamylamine) were given 10 min before administration of the ginsenosides to analyze the contribution of spinal adrenergic and cholinergic receptors on the antinociceptive effect of ginsenosides.RESULTS:
Paw incision decreased withdrawal threshold in incised site of paw, but no change of withdrawal threshold was not seen in non-incised site. The intrathecal ginsenosides increased withdrawal threshold of the incised paw in a dose-dependent manner. Pre-treatment with both prazosin and intrathecal yohimbine antagonized the anti-nociceptive effect of the ginsenosides. However, pre-treatments with atropine or mecamylamine had any effect on the antinociceptive activity of ginsenosides.CONCLUSIONS:
Intrathecal ginsenosides are effective in attenuation of postoperative pain induced in the rat model. Anti-nociceptive action of ginsenosides is partially mediated by spinal adrenergic receptors, but does not appear to be related to spinal cholinergic receptors.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dor Pós-Operatória
/
Atropina
/
Medula Espinal
/
Ioimbina
/
Prazosina
/
Receptores Adrenérgicos
/
Receptores Colinérgicos
/
Receptores Nicotínicos
/
Receptores Muscarínicos
/
Ratos Sprague-Dawley
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2013
Tipo de documento:
Artigo
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