Your browser doesn't support javascript.
loading
Administration of four different doses of gabapentin reduces awakening from breakthrough pain and adverse effects in outpatients with neuropathic pain during the initial titration / 대한마취과학회지
Korean Journal of Anesthesiology ; : 48-54, 2013.
Artigo em Inglês | WPRIM | ID: wpr-85961
ABSTRACT

BACKGROUND:

Gabapentin is a safe and well-tolerated anticonvulsant with a wide therapeutic index, and it is used for neuropathic pain. The aim of this study was to compare previous dosing methods with the administration of four different doses of gabapentin while maintaining the same maximum daily dose for the safe administration of high doses of the medication.

METHODS:

The subjects were outpatients with various neuropathic pain syndromes, with at least two of the following symptoms allodynia, burning pain, shooting pain, or hyperalgesia. The TID group received equal doses of gabapentin 3 times per day, while the QID group received 4 different doses of gabapentin per day. The pain score, frequency of breakthrough pain (BTP), severity and the duration of pain, sleep disturbance due to nocturnal pain, and adverse effects were recorded each day.

RESULTS:

The average daily pain score and sleep disturbance were significantly reduced in the QID group between days 3 and 10 of the experiment. The adverse effects of the medication were also reduced in the QID group. However, the frequency of BTP and severity and duration of pain were not significantly different between two groups.

CONCLUSIONS:

Administration of 4 different doses of gabapentin during the initial titration in outpatients with neuropathic pain resulted in a significant reduction in awakening from breakthrough pain and a reduction in the adverse effects of the medication.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pacientes Ambulatoriais / Queimaduras / Esquema de Medicação / Ácidos Cicloexanocarboxílicos / Dor Irruptiva / Assistência Ambulatorial / Ácido gama-Aminobutírico / Aminas / Hiperalgesia / Neuralgia Limite: Humanos Idioma: Inglês Revista: Korean Journal of Anesthesiology Ano de publicação: 2013 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pacientes Ambulatoriais / Queimaduras / Esquema de Medicação / Ácidos Cicloexanocarboxílicos / Dor Irruptiva / Assistência Ambulatorial / Ácido gama-Aminobutírico / Aminas / Hiperalgesia / Neuralgia Limite: Humanos Idioma: Inglês Revista: Korean Journal of Anesthesiology Ano de publicação: 2013 Tipo de documento: Artigo